Estimation Of Cmax Defined In Just 3 Words
The equations for both approaches are listed in TableII. For renally excreted drugs, a physiologically based IVIVE approach (20,34) was developed to predict human renal clearance (CLR). The relation between hepatic clearance (CLH) and CLint, in vivo depends on three mathematical models used for describing the disposition of drug in the liver (23). Incorporation of […]